HYAJOINT Plus® is a synovial fluid supplement, also known as a viscosupplement, that replaces the hyaluronic acid naturally present in the joint. The treatment requires a single injection into the synovial cavity of the joint knee 3.
HYAJOINT Plus® reduces knee pain and improves mobility for at least 6 months 1,2.
Active Ingredient
Sodium hyaluronate 60mg
HA Concentration
60mg/3mL (2%)
Injection Regimen
One single injection per treatment for adult into the OA knee joint
Package
3mL x 1 syringe
*This product is a class III medical device. CE marked (Notified body n°2797) in accordance with the rules and regulation in effect. 
HYAJOINT Plus® is synthesised by a novel cross-linking process using 1,4-butanediol diglycidyl ether (BDDE) to create an antidegradation feature. The patented CHAPTM (Cross-linked Hyaluronic Acid Platform) process prolongs the degradation time by carefully transforming linear hyaluronic acid to crosslinked hyaluronic acid and thus increasing the molecular weight. This cross-linking technology enables the creation of a viscous gel with increased density (2% HA, 20mg/ml)1,2. The carefully controlled cross-linked hyaluronic acid increases the viscoelastic properties of the synovial fluid reducing pain and restoring knee joint mobility 1,2.
*For more information, please consult the available patent.
Linear hyaluronic acid before cross-linking.
Cross-Linking technology with less BDDE, minimising the amount of BDDE residue.
The values of VAS score (mm) are given as the mean ± standard deviation. For statistical detail, please refer to the brochure.
Better improvement of pain relief by 33.3 mm on VAS score in patients treated with HYAJOINT Plus® compared to 23.4 mm in the Synvisc-One® group at 6 months (mean difference between groups -6.6; p=0.045).2
The frequencies and types of adverse events were comparable between Synvisc-One® and HYAJOINT Plus® groups. The majority of adverse events were mild or moderate, lasted 1 to 3 days, and resolved spontaneously or responded well to simple analgesics. The adverse events reported in each group were joint pain, joint swelling, joint stiffness, limb weakness, back pain. Twelve patients ( 9 treated with Synvisc-One® and 3 treated with HYAJOINT Plus®) developed joint effusion within 1 week after the injection, all infections revolved except for 2 patients treated with Synvisc-One® who required arthrocentesis for pain relief. No allergies, pseudosepsis or serious adverse events occurred during the study in either group.2
6 months after injection of HYAJOINT Plus®, the WOMAC pain score (Western Ontario and McMaster Universities Osteoarthritis Index) was significantly reduced compared to the baseline (from 7.62 to 3.57; P<0.001)1.
The Single Leg Stance (SLS) duration was significantly improved at 6 months after HYAJOINT Plus® injection compared to the baseline (from 14.95 to 26.37 sec; p=0.008)1.
The mean VAS decreased by 28.45 mm from baseline at 6-month follow-up (from 60.12 to 31.67mm; p<0.001)1.
The values of WOMAC pain score (points) are given as the mean ± standard deviation (7.62±0.49 and 3.57 ±0.40 at baseline and 6 months respectively) in 46 patients assessed using a Bonferroni post-hoc test. Adapted from Tuan et al, 2018.
The values of SLS duration (sec) are given as the mean ± standard deviation (14.95±2.97 and 26.37±3.83 at baseline and 6 months respectively) in 46 patients assessed using a Bonferroni post-hoc test. Adapted from Tuan et al, 2018.
The values of VAS score (mm) are given as the mean ± standard deviation (60.12±2.31 and 31.67±25.02 at baseline and 6 months respectively) in 46 patients assessed using repeated measures one-way ANOVA and a Bonferroni post-hoc test. Adapted from Tuan et al, 2018.
References:
1. Tuan S., Liou I., Su H., Tsai Y., Chen G. and Sun S._Improvement of self-reported functional scores and thickening of quadriceps and femoral intercondylar cartilage under ultrasonography after single intra-articular injection of a novel crosslinked hyaluronic acid in the treatment of the knee osteoarthritis. JBMR._2018 ; 31 : 709-718
3. Instruction for use HYAJOINT Plus® (PIHPF-10(01) 20190801)
2. Sun, S.-F., Hsu, C.-W., Lin, H.-S., Liou I.-H., Chen, Y.-H. and Hung C.-L._Comparison of Single Intra-Articular Injection ofNovel Hyaluronan (HYA-JOINT Plus) with Synvisc-One for Knee Osteoarthritis. JBJS._2017 ; 99(6) : 462-471
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SciViscion Biotech Inc.
9, South 6th Rd. K.E.P.Z.,
Kaohsiung 806
TAIWAN, R.O.C
Obelis s.a
Bd. General Whahls 5,
1030 Brussels – BELGIUM
Tel : +32 2732 5954
Fax: + 32 2732 6003
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MACO PHARMA S.A.S,
Rue Lorthiois
59420 Mouvaux – FRANCE
Tel : +33(0) 3 20 11 84 30
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