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THERAFLEX UV-Platelets system

The THERAFLEX UV-Platelets system is not available on the market

The THERAFLEX UV-Platelets system is intended to inactivate a broad spectrum of pathogens as well as residual donor leucocytes in platelet concentrates (apheresis or Buffy-coat) suspended in Platelet Additive Solution (PAS) in order to reduce the risk of transfusion-transmitted infection and leucocyte-associated adverse reactions

Exposure to UV light causes DNA damage, inactivating bacteria, viruses, parasites and leukocytes.

List of references

  • Brixner V, Bug G, Pohler P, Krämer D, Metzner B, Voss A, Casper J, Ritter U, Klein S, Alakel N, Peceny R, Derigs HG, Stegelmann F, Wolf M, Schrezenmeier H, Thiele T, Seifried E, Kapels H-H, Döscher A, Petershofen EK, Müller TH, Seltsam A. Efficacy of UVC-treated, pathogen-reduced platelets versus untreated platelets: a randomized controlled non-inferiority trial. Haematologica. 2021; 106(4):1086-1096.
  • Eickmann M, Gravemann U, Handke W, Tolksdorf F, Reichenberg S, Müller TH, Seltsam A. Inactivation of three emerging viruses – severe acute respiratory syndrome coronavirus, Crimean-Congo haemorrhagic fever virus and Nipah virus – in platelet concentrates by ultraviolet C light and in plasma by methylene blue plus visible light. Vox Sang. 2020 Apr; 115(3):146-151.
  • Praditya D, Friesland M, Gravemann, U, Handke W, Todt D, Behrendt P, Müller TH, Steinmann E and Seltsam A, Hepatitis E virus is effectively inactivated in platelet concentrates by ultraviolet C light. Vox Sang. 2020; 115:555-561.
  • Gravemann U, Handke W, Müller TH, Seltsam A. Bacterial inactivation of platelet concentrates with the THERAFLEX UV-Platelets pathogen inactivation system. Transfusion. 2019; 59(4):1324-1332.
  • Gravemann U, Handke W, Lambrecht B, Schmidt JP, Muller TH, Seltsam A. Ultraviolet C light efficiently inactivates non enveloped Hepatitis A virus and Feline calicivirus in platelet concentrates. Transfusion. 2018; 58(11):2669-74.
  • Pohler P, Müller M, Winkler C, Schaudien D, Sewald K, Müller T H, & Seltsam A. Pathogen reduction by ultraviolet C light effectively inactivates human white blood cells in platelet products. Transfusion 2015; 55(2):337-347.
  • Bashir S, Cookson P, Wiltshire M, Hawkins L, Sonoda L, Thomas S, Seltsam A, Tolksdorf F, Williamson LM, Cardigan R. Pathogen inactivation of platelets using ultraviolet C light: effect on in vitro function and recovery and survival of platelets. Transfusion 2013; 53(5):990–1000.
  • Faddy HM, Fryk JJ, Prow NA, Watterson D, Young PR, Hall RA, Tolksdorf F, Sumian C, Gravemann U, Seltsam A, Marks DC. Inactivation of Dengue, Chikungunya, and Ross River viruses in platelet concentrates after treatment with ultraviolet C light. Transfusion 2016; 56(6 Pt 2):1548-55.2

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