Authors

A. Lotens¹, T. Najdovski¹, N. Valensart¹, N. Cellier¹, C. Sumian², Q. Brebant², C. Naegelen³,C. Cretenet³, N.Marpaux³

¹Service du Sang, Belgian Red Cross, Namur, Belgium
²MacoPharma, Tourcoing, France
³EFS Bourgogne Franche Comté, Besançon, France

Introduction and Aim :

→The plasticizer di(2-ethylhexyl)-phthalate (DEHP) is a common component of blood bags.

→Exposure to DEHP is raising concern on about its potential carcinogenicity and reprotoxicity.

→DEHP will be banned following the Registration, Evaluation, Authorisation and Restriction of Chemicals (REACH)
regulation in 2030.

→AIM:Assess the impact of different process preparations on the RBC quality stored in di(2-ethylhexyl)-terephthalate DEHT (Transfufol DEHT 3126 from RENOLIT Nederland B.V.)/PAGGSM (Phosphate Adenine Glucose Guanosine Saline Mannitol)

Methods :

Results :

Conclusion :

There is no significant impact on the different process preparations on the RCC quality with a combination of DEHT-PAGGSM, outside of the potassium that is more pronounced when the process is performed above 12 hours after WB collection.