IN VITRO QUALITY DATA AND CLINICAL EXPERIENCE
• Reports of haemovigilance from several countries demonstrate a significant reduction in the rate of allergic events wih platelets suspended in PAS compared to platelets suspended in plasma.
• Platelet concentrates from Buffy-Coat in SSP+ additive solution show superior in vitro parameters when compared with those stored in plasma. (Storage of platelet concentrates -Present and future, P. Van der Meer.)
• Novel PAS containing glucose, calcium and bicarbonate does not seem to be associated with improved in vitro results as compared to SSP+ when PLTs are stored with 35% plasma inclusion. (Platelet storage media, H. Gulliksson.)
• HSR, regarded as one of the best single in vitro parameters to predict post-transfusion efficacy, is higher after 7-day storage in SSP+ as compared to Intersol. (in vitro and in vivo effects of potassium and magnesium on storage up to 7 days of apheresis platelet concentrates in platelet additive solution, B. Diedrich et al.)
• SSP+ is effective for both preserving the in vitro properties of PLTs and preventing accelerated glycolysis. (Parallel comparison of apheresis collected platelet concentrates stored in four different additive solutions, M. Nogawa et al.)
• Storage of PLTs in SSP+ improved the quality of PCs in terms of better maintained PLT count, lower glucose metabolism, lower spontaneous activation, and improved response to a PLT agonist compared to PLTs in T-Sol. (in vitro properties of platelets stored in three different additive solutions, N. Tynngard et al.)