Extracorporeal Photopheresis Off-line technique by Maco Pharma

Over the last years, extracorporeal photopheresis (ECP) has been recognised by the scientific community as therapeutic option to treat various disorders.

Recommendations from a UK group of photopheresis experts summarize the positive impact of the technique on the treatment on several pathologies.1

(1) Scarisbrick et al. U.K. consensus statement on the use of extracorporeal photopheresis for treatment of cutaneous T-cell lymphoma and chronic graft-versus-host disease. 2008.

Cutaneous T-Cell Lymphoma (Sézary syndrome, mycosis fongoides) in first-line treatment in erythrodermic stage IIIA or IIIB*, and in stage IVA1-IVA2*

* ISCL/EORTC classification

Graft versus Host Disease :
– in second line of the chronic form,
– in second line therapy in patients refractory to corticosteroids (2 mg/kg/day) and calcineurin inhibitors
of the acute form

Solid organ transplantation in lung transplantation, main indication in patients with bronchiolitis obliterans syndrome (BOS)

Macopharma has developed a range of products dedicated to the off-line Photopheresis technique

ECP is based on the exposure of Buffy coat collected by an apheresis device used in health care facilities to the photosensitizing agent 8-MOP and UVA irradiation.

The cells are reinfused to the patient after irradiation.

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Cell Culture

Maco Pharma’s cell culture range provides a solution
for every step of your process, from cell seeding to harvesting

Working in collaboration with
cell therapy centres, research teams
and hospitals,

A Maco Pharma’s Biotherapy division developed a whole range of disposables and media for stem cell collection, processing and expansion.

To cope with this challenge we developed a secure cell culture concept with human platelet lysate and xeno-free culture media dedicated to specific stem cell populations.

These strong partnerships enable Maco Pharma Biotherapy to design value solutions to accompany researchers and health professionals from cell collection to cell injection into a patient.

Human Platelet Lysate

MultiPL’ range

Benefiting from 40 years of
expertise on transfusion medicine

With a strong knowledge on platelets and on pathogen inactivation, Maco Pharma Biotherapy developed a range of human platelet lysates: MultiPL’, to expand multiple cell types.

The full MultiPL’ range is produced from qualified donors and platelets intended for human transfusion.


Virally inactivated MultiPL’100i

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Media and Buffers

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Bio Banking

Human tissues and cells for human application can save lives or restore essential functions*

*Guide to the quality and safety of tissues and cells for human application – 2015 – European Directorate for the Quality of Medicines & HealthCare – Council of Europe

Nearly 20 years ago, Maco Pharma developed medical devices dedicated to the long term storage of cells and tissues at very low temperatures.

Made of EVA (Ethylene Vinyl Acetate), these freezing bags are designed to tolerate long term storage at temperatures down to -196°C, facilitating the optimal storage of cells and tissues.

Cell Freezing and Banking

Maco Biotech Freezing - Eva Bags

EVA bags from Maco Pharma are indicated for the storage of
cells at very low temperatures in view of a transplant.

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Tissue Freezing and Banking

Maco Biotech Freezing - Eva Bags

EVA bags from Maco Pharma are indicated for the storage of
tissues at very low temperatures in view of a transplant.

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Sealers and Additional Products

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Cord Blood

Maco Pharma’s cord blood range provides products to collect and to cryopreserve stem cells of the umbilical cord blood.

As one of the world’s first companies to provide cord blood banks with dedicated collection kits, Maco Pharma has been a leader in the field for more than fifteen years.

Based on the company transfusion deep knowledge, collection bags with one or two needles were designed to collect cord blood from both caesarean section deliveries and natural births.

Collection Bags

Macopharma collection bags are specifically designed for the collection of human umbilical cord blood. The collection bags are sterile and suitable for vaginal births and caesarean section deliveries in operating theaters.

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USA – FDA NDA Approved Collection Bags

Our cord blood collection bags include a variety of innovative features. Macopharma provides two designs of bags developed specifically for cord blood collection. Graduations to provide an indication of collected volume, an additional 12G needle for the MSC127D reference but also an additional CPD rinsing pouch. For both references, the exterior of the bag is sterile inside an inner overwrap making the product suitable for caesarian section deliveries.
Our cord blood collection bags are FDA NDA approved.
Our dual needle cord blood collection bag is FDA NDA approved.

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The MACOPRESS Smarter (MPS) is a device intended for the automated
component separation of human umbilical cord blood.

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Freezing and banking


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